| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857257 | Regulatory Toxicology and Pharmacology | 2012 | 15 Pages |
Abstract
⺠Key factors in planning in vivo experiments unified in a practical flow diagram. ⺠Checklist presented for optimising output from in vivo experiments. ⺠Endpoint-specific and generic variability identified for four endpoints. ⺠Application of 3Rs in obtaining pharmacological or toxicological data.
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Authors
Judith C. Madden, Mark Hewitt, Katarzyna Przybylak, Rob J. Vandebriel, Aldert H. Piersma, Mark T.D. Cronin,