| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857386 | Regulatory Toxicology and Pharmacology | 2011 | 14 Pages |
Abstract
⺠Polymeric MDI aerosol has extensively been studied to interrelate acute and chronic pulmonary irritation. ⺠Acute lung irritation by polymeric MDI is 1-order of magnitude less that than of monomeric MDI. ⺠Cumulative and acute threshold mode of actions have been debated. ⺠This study compared to use PBPK modeling to predict pulmonary toxicity. ⺠This analysis concludes that long-term effects depend on the acute irritation threshold.
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Authors
Jürgen Pauluhn,