| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857448 | Regulatory Toxicology and Pharmacology | 2013 | 17 Pages |
Abstract
An ADI value of 20 mg/kg bw was concluded from two alternative approaches. Daily exposure from use in dietary supplements is estimated as up to 10.0 mg/kg bw in adults and 13.3 mg/kg bw in children. There would therefore appear to be no safety concerns under the intended conditions of use. The information provided is intended to support an evaluation that the substance may be “generally recognized as safe” (GRAS).
Keywords
IUPACBCAEFSAGPCMMATDItotal daily intakeSCFMOSNOAELOECDGLPNMTDNFCSDutch National Food Consumption SurveyPh. Eur.generally recognised as safeRIVMthymidine kinase locusDMFDMEMCASGRASLD50PCEMNPCEDMSOmicronucleated polychromatic erythrocytesInternational Union of Pure and Applied ChemistryEthyl acrylateEuropean Food Safety Authoritypolychromatic erythrocytesUnited StatesUnited States of AmericaUSASafetybicinchoninic acidGood Laboratory PracticeMargin of safetychemical abstract servicedimethyl sulphoxideOrganisation for Economic Co-operation and DevelopmentCoating agentEuropean PharmacopoeiaMMA, Methyl methacrylateDulbecco’s modified eagle’s mediumSEMICHFood additivemedian lethal dosescanning electron microscopeNo observed adverse effect levelbody weightUnited KingdomGel permeation chromatographyScientific Committee on FoodInternational Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use
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Authors
Johanna Eisele, Geoff Haynes, Knut Kreuzer, Tiana Rosamilia,