Article ID Journal Published Year Pages File Type
5857492 Regulatory Toxicology and Pharmacology 2013 9 Pages PDF
Abstract
► We developed a simple pharmacokinetic (PBPK) model of melengestrol acetate (MGA). ► Rat or mouse PBPK model of MGA was scaled to human model to predict in humans. ► MGA elimination in humans was estimated to be slow compared with those in rodents. ► Concentrations of MGA were evaluated by chimeric mice with humanized liver. ► The simplified human PBPK modeling is useful for risk evaluation of MGA.
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Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Preview
Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling
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