| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857588 | Regulatory Toxicology and Pharmacology | 2012 | 11 Pages |
Abstract
⺠The in vitro and in vivo safety assessment of strain Bacteroides xylanisolvens DSM 23964 was investigated. ⺠The strain DSM 23964 shows no mutagenic, clastogenic, or toxicological effects. ⺠The strain DSM 23964 is sensitive to the defense system of the host. ⺠Results support the safety of the potential use of B. xylanisolvens DSM 23964 as human probiotic. ⺠The strain B. xylanisolvens DSM 23964 may be developed as the first natural probiotic strain of the genus Bacteroides.
Keywords
CRLNMRIPBSCFUGCPNOAELi.p.GRASOECDGLPDMSOSafetyBacteroidesGood Laboratory PracticeMutagenicityintraperitonealDimethyl sulfoxideWorld Health OrganizationFood and Agriculture OrganizationOrganization for Economic Cooperation and DevelopmentToxicityAbscess formationgood clinical practiceFAOClastogenic activityPhosphate-buffered salineICHnaval medical research instituteNo observed adverse effect levelcolony-forming unitpolymerase chain reactionPCRbody weightProbioticsoptical densityEuropean CommissionInternational Conference on HarmonizationWHO
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Philippe Ulsemer, Kawe Toutounian, Jens Schmidt, Jost Leuschner, Uwe Karsten, Steffen Goletz,