| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857672 | Regulatory Toxicology and Pharmacology | 2013 | 17 Pages |
Abstract
⺠We develop a PBPK/PD model for nicotine for the i.v., oral, inhalation routes. ⺠Bayesian optimization produced distributions for key metabolism parameters. ⺠The affect of variability in smoking behavior and nicotine yield was explored. ⺠Nicotine dosimetry is a crucial element of a risk assessment strategy for tobacco.
Keywords
i.v.QCCMCMCQBCPBPDVDCVMCQMCTobRegFNCHROVFCnAChRsPBPKMLEAUCCardiac outputBayesian optimizationIntravenousMarkov chain Monte CarloWorld Health OrganizationPartition coefficientSensitivity coefficientpharmacodynamicPhysiologically based pharmacokineticmouth level exposurearea under the curveNicotinebody weightVeinKantWHOnicotinic acetylcholine receptorsReceptor binding
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Authors
Justin G. Teeguarden, Conrad J. Housand, Jordan N. Smith, Paul M. Hinderliter, Rudy Gunawan, Charles A. Timchalk,