| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857686 | Regulatory Toxicology and Pharmacology | 2013 | 8 Pages |
Abstract
⺠Thujone (e.g. in absinthe) has a long-term reputation as a neurotoxicant. ⺠α-Thujone is rapidly acting modulator of the GABAA-receptor. ⺠Thujone occurs widely in essential oils of medicinal and botanical plants. ⺠Analytical techniques are available to detect α- and β-thujone in various matrices. ⺠Regulatory status needs re-assessment based on focussed investigations.
Keywords
Theoretical Maximum Daily IntakehMPCno-observed-effect-levelSCFHS-SPMENTPgamma-aminobutyric acid type A receptorTMDICyPEMATDINLMBMDLNOELGC–FIDGC–MSLC/MSADIGas chromatography–flame ionization detectorEuropean Medicines agencyRisk assessmentNational Toxicology ProgramThujoneAcceptable daily intakeCNSToxicityCytochrome P450central nerve systemliquid chromatography–mass spectrometrygas chromatography–mass spectrometryPharmacokineticsMetabolismTolerable daily intakeNational Library of MedicineScientific Committee on FoodGABAA
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Authors
Olavi Pelkonen, Khaled Abass, Jacqueline Wiesner,