| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857744 | Regulatory Toxicology and Pharmacology | 2012 | 11 Pages |
Abstract
⺠We reported the cellular responses to treatment with cigarette smoke and smokeless TPPs in short-term cell cultures. ⺠Combustible TPPS induced more DNA damage, IL8 secretion and cytotoxicity than smokeless TPPs. ⺠PBMC subsets exhibit cytotoxicity to treatment with combustible TPPs: CD4 > CD8 > monocytes > NKcells.
Keywords
TPMTSNAsTNFPBMCsIRBEC50CASDMSOTPPsinterleukincardio vascular diseaseCOPDChronic obstructive pulmonary diseaseTobacco specific nitrosaminessmokeless tobaccotumor necrotic factorcluster of differentiationDimethyl sulfoxidetotal particulate matterCVDperipheral blood mononuclear cellsNK cellsNatural killer cellsCytotoxicityCell deathPolycyclic aromatic hydrocarbonsPAHs
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Authors
Subhashini Arimilli, Brad E. Damratoski, Betsy Bombick, Michael F. Borgerding, G.L. Prasad,