Article ID Journal Published Year Pages File Type
5857752 Regulatory Toxicology and Pharmacology 2012 10 Pages PDF
Abstract
► HSP90 inhibition by 17-AAG decreases cellular Rad51 expression. ► 17-AAG downregulates the DNA repair capacity of human lung cancer cells. ► Rad51 plays a protective role in 17-AAG-induced cytotoxicity.
Keywords
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Preview
HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells
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