| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857761 | Regulatory Toxicology and Pharmacology | 2012 | 12 Pages |
Abstract
⺠We evaluated the human health risk of exposure to TDI in polyurethane (PU) foam. ⺠Toxicity benchmarks for non-cancer and cancer endpoints were determined. ⺠Previous emission testing results determined dermal and inhalation exposures. ⺠Calculated dermal and inhalation exposures were below toxicological benchmarks. ⺠Sleeping on a PU foam mattress for a lifetime is unlikely to pose health risks.
Keywords
LOAELno expected sensitization induction levelBMDSGPMTlowest observable adverse effect levelNOELOELLLNANOAELFEV1MOSRFCLMSBHRPODNTPMDLTWAFVCLocal lymph node assayNational Toxicology ProgramBronchial hyperreactivityGuinea pig maximization testMargin of safetyForced expiratory volumeforced expiratory volume in one secondforced vital capacityCancer slope factorReference concentrationFevLaddCSFMethod Detection LimitOccupational exposure limitNESILPoint of departureNo observed effect levelNo observed adverse effect levelPolyurethanes
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Authors
Scott M. Arnold, Michael A. Collins, Cynthia Graham, Athena T. Jolly, Ralph J. Parod, Alan Poole, Thomas Schupp, Ronald N. Shiotsuka, Michael R. Woolhiser,