| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5857763 | Regulatory Toxicology and Pharmacology | 2012 | 7 Pages |
Abstract
⺠Introduction of quantitative-risk-assessment for skin sensitization by hair dyes. ⺠Measured-exposure-level (MEL) concept applied to determine hair dyeing use exposure. ⺠Quantification of skin sensitization risk based on direct comparison of MEL and NESIL. ⺠Proof-of-concept with p-phenylenediamine and resorcinol reflects market observation.
Keywords
CelAcceptable Exposure Levelno expected sensitization induction levelSCCPAELHRIPTWOEAOOQRALLNASAFhMTMELeC3DMFSLSOECDPPDSCCsDMSOpara-PhenylenediamineLocal lymph node assayEuropean UnionQuantitative risk assessmentHuman Repeated Insult Patch TestSkin sensitizationAllergic contact dermatitisdimethylformamideDimethylsulfoxideResorcinolHair dyesOrganisation for Economic Co-operation and Developmentsodium lauryl sulfatestimulation indexStratum corneumNESILWeight-of-evidence
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Carsten Goebel, Thomas L. Diepgen, Maya Krasteva, Harald Schlatter, Jean-Francois Nicolas, Brunhilde Blömeke, Pieter Jan Coenraads, Axel Schnuch, James S. Taylor, Jacquemine Pungier, Rolf Fautz, Anne Fuchs, Werner Schuh, G. Frank Gerberick, Ian Kimber,