Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5857805 | Regulatory Toxicology and Pharmacology | 2010 | 8 Pages |
Abstract
We studied an acute and subchronic oral toxicity of Mequindox (MEQ), a quinoxaline 1,4-dioxide antimicrobial promoter, in Wistar rats according to OECD guidelines. For acute toxicity study, single doses of MEQ at 175, 550 and 2000Â mg/kg b.w. were administered to rats by oral gavage. The calculated LD50 was 550Â mg/kg b.w. In subchronic study, rats were fed diets containing 0, 55, 110 or 275Â mg MEQ/kg. There was a reduction in body weight of rats fed 275Â mg MEQ/kg diet. At 90Â days autopsy, a significant decrease in the kidney weight was observed in males while an increase in relative liver and adrenal weights were observed in females fed 275Â mg MEQ/kg diet. There was a significant increased in alanineaminotransferase (ALT) and malondialdehyde (MDA) concentrations in males, superoxide dismutase (SOD) activities in females, and aspartateaminotransferase (AST) levels in serum of both genders fed 275Â mg MEQ/kg diet. Other toxic effects of 275Â mg MEQ/kg diet included significant decrease in sodium and significant increase in potassium concentrations in serum in both genders. We may conclude that MEQ can induce hepatic and adrenal histological changes as well as leaking of different serum constituents in Wistar rats.
Keywords
CREAHCTWBCRDWALBRBCALTTBAb.w.MCHPLTPDWMCHCMPVCHOLMCVNOAELMEQQuinoxalinesMDAH&EASTAspartate aminotransferaseAlanine aminotransferaseAlbuminALPAlkaline phosphataseEDTAUric acidThiobarbituric acidanalysis of varianceANOVAred blood cell countAcuteMean corpuscular volumeBUNSubchronicSODSodiumToxicitySuperoxide dismutasePlatelet countWhite blood cell countPlatelet distribution widthInorganic phosphorusmalondialdehydemean platelet volumemean corpuscular hemoglobinWistar ratsMequindoxMean corpuscular hemoglobin concentrationblood urea nitrogenhematocritHematoxylin and EosinHemoglobinHgbNo observed adverse effect levelbody weightPotassiumcreatininetotal proteinChloridecholesterolCalciumGluGlucose
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Authors
Awais Ihsan, Xu Wang, Xian-ju Huang, Yu Liu, Qin Liu, Wen Zhou, Zong-hui Yuan,