Evaluation of the protective effect of thiamine pyrophosphate based on the biochemical analysis of rabbit foetuses at 30 days of gestation

This study evaluated the effects of thiamine pyrophosphate (PPT) on the biochemical profiles of full-term rabbit foetuses that were subjected to experimental ischemia followed by 24 h reperfusion. A total of 16 gestating rabbit dams were divided into two groups, one of which was treated by administering PPT and subjected to a process ischemia. During this interval, fetal blood samples were drawn from each dam (in the ischemia group) at 0, 15 and 45 min. Ischemia for 15 and 45 min was not associated with changes in lactate levels of the Ischemia group foetuses. However, in the foetuses in the reperfusion groups without PPT lactate levels were significantly higher after 15 and 45 min of arterial occlusion compared to time zero. These results demonstrate that PTT alters some acute and some longer-term biochemical outcomes of uterine ischemia perhaps important in preserving energy metabolism under hypoxic conditions.