Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5857964 | Reproductive Toxicology | 2016 | 13 Pages |
Abstract
Several studies have highlighted the negative effects of bisphenol A (BPA), a chemical compound with estrogenic activity, on reproductive health. To elucidate the impact of BPA on spermatogenesis' establishment and mechanisms of action of BPA and 17β-estradiol (E2), as both can be found in the environment, we exposed rats to BPA (50 μg/kg bw/day of BPA), E2 (20 μg/kg bw/day of E2) and BPA + E2 from 15 to 30 days post-partum. Histological and gene expression studies revealed that BPA and BPA + E2 exposures promoted spermatogenesis establishment whereas E2 alone delayed it. Then, a decrease in gene expression of blood-testis-barrier (BTB) proteins was observed in all treated groups. Therefore, our study has demonstrated a differential effect of BPA and E2 exposures on spermatogenesis establishment in prepubertal rats and a deleterious effect of these chemicals on BTB establishment. Thus, the effects of BPA seem to be mediated by receptors other than estrogen receptors.
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Authors
Vanessa Brouard, Isabelle Guénon, Hélène Bouraima-Lelong, Christelle Delalande,