Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5857970 | Reproductive Toxicology | 2016 | 42 Pages |
Abstract
Polybrominated diphenyl ether flame-retardants (PBDEs) are thyroid-disrupting environmental chemicals. We investigated the effects of postnatal exposure to DE-71 (a mixture of tetra- and penta-brominated congeners), n-propylthiouracil (PTU) and thyroxine (T4) replacement on open-field (OF) and radial maze (RAM) tests. Wistar rats (5 males/5 females per litter, 32 litters) were treated orally (PND 5-22) with PTU (4 mg/kg bw/d), DE-71 (30 mg/kg bw/d), with and without co-administration of T4 (15 μg/kg bw/d, sc). PTU depressed T4 serum levels and body weight gain and enlarged thyroid gland. Although decreasing T4 levels, DE-71 did not change thyroid and body weights. PTU-treated rats showed hyperactivity (PND 42 and 70), and working and reference memory learning deficits (RAM, PND 100). Although not altering motor activity and working memory, DE-71 caused a reference memory deficit (females only). T4 co-administration averted hypothyroxinemia and long-term cognitive deficits caused by PTU and DE-71.
Keywords
TSHethoxyresorufin-O-dealkylasePRODLiver enzyme inductionPolychlorinated dibenzo-p-dioxins/furansPTUDE-71DIOPBDEsERODUGTPCBsPNDPBDEPCDD/FsOpen field testPOPsPersistent organic pollutantsFlame retardantsPolychlorinated biphenylsTriiodothyroninethyroxineCNSPolybrominated diphenyl etherBehaviorRamgestation daypostnatal daycentral nervous systemDevelopmental neurotoxicityThyroid functionthyroid stimulating hormonebody weightEight-arm radial mazeLearning
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Authors
Andressa S. de-Miranda, Sergio N. Kuriyama, Camille S. da-Silva, Monicke S.C. do-Nascimento, Thiago E.M. Parente, Francisco J.R. Paumgartten,