Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5858577 | Reproductive Toxicology | 2013 | 97 Pages |
Abstract
There is growing evidence that bisphenol A (BPA) may adversely affect humans. BPA is an endocrine disruptor that has been shown to be harmful in laboratory animal studies. Until recently, there were relatively few epidemiological studies examining the relationship between BPA and health effects in humans. However, in the last year, the number of these studies has more than doubled. A comprehensive literature search found 91 studies linking BPA to human health; 53 published within the last year. This review outlines this body of literature, showing associations between BPA exposure and adverse perinatal, childhood, and adult health outcomes, including reproductive and developmental effects, metabolic disease, and other health effects. These studies encompass both prenatal and postnatal exposures, and include several study designs and population types. While it is difficult to make causal links with epidemiological studies, the growing human literature correlating environmental BPA exposure to adverse effects in humans, along with laboratory studies in many species including primates, provides increasing support that environmental BPA exposure can be harmful to humans, especially in regards to behavioral and other effects in children.
Keywords
BPAIL-6SCEPFOAPFOSSBPDBPHDL8-OHdGFAINHANESTSHEFsSRSCBCLECNTDIDHEASCHDBASC-2HbA1cBRIEF-PUCSFNNNSMGHPCOSSHBGPIVUSRTPCR17-beta estradiolbisGMASFFEPIC-Norfolk studyFDAMDAVCLCHAMACOSiSCINICU Network Neurobehavioral ScaleOHATtriidothyronineHRVhigh-density lipoproteinAntinuclear antibodiesANAHumanEpidemiologyHCGinterleukin-6BADGEbisphenol A diglycidyl etherBisphenol Acoronary artery diseasecoronary heart diseasecardiovascular diseaseMetabolic diseaseSister chromatid exchangeintracytoplasmic sperm injectionfree testosteroneReproductionThyroidthyroxineHomesUniversity of California, San FranciscoCVDDevelopmentFood and Drug AdministrationPolycystic ovary syndromedehydroepiandrosterone sulfatePerfluorooctane sulfonateCMVcytomegalovirusbody mass indexBMICADAnogenital distancediastolic blood pressuresystolic blood pressureIn vitro fertilizationIVFLow-density lipoproteinLDLmalondialdehydeTotal testosteroneTolerable daily intakeSocial Responsiveness ScaleEndocrine-disrupting chemicalsheart rate variabilityHemoglobin A1cHCG, Human chorionic gonadotropinfollicle-stimulating hormoneluteinizing hormonesex hormone binding globulinthyroid stimulating hormoneFSHEndometrial hyperplasiareverse transcription polymerase chain reactionPerfluorooctanoic acidC-reactive proteinCRPChild Behavior ChecklistAGDUSEPAEstrogen receptor
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Authors
Johanna R. Rochester,