| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5858912 | Reproductive Toxicology | 2014 | 7 Pages |
â¢Lower body weight.â¢Lower organ coefficient of ovary.â¢Higher GnRH level in the hypothalamus.â¢Higher mRNA and protein levels of GnRHR in the pituitary.â¢Lower serum sex hormone levels. Thus, DEHP affects the function of hypothalamus-pituitary-ovarian axis in adult female rat.
Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on hypothalamus-pituitary-ovarian axis in adult female rats. Compared with control rats, the DEHP-treated rats showed: (1) lower body weight; (2) lower organ coefficient of ovary; (3) higher GnRH level in the hypothalamus; (4) higher mRNA and protein levels of GnRHR in the pituitary; and (5) lower serum sex hormone levels. Our data reveal that DEHP exposure may lead to the disruption of estrogen biosynthesis pathways in female rats and imbalance of hypothalamus-pituitary-ovarian axis. DEHP may impose negative influence on the development and function of the reproductive system in female rats.
