| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5858949 | Toxicology | 2016 | 8 Pages |
Abstract
We concluded that arecoline induced tubulointerstitial fibrosis in mice while arecoline-induced TGF-β and pro-fibrotic proteins (fibronectin, PAI1) are dependent on JNK in LLC-PK1 cells.
Keywords
PAI1TGF-βJnkcox2ERK3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromidec-Jun N-terminal kinaseDMSOMTTarecolinechronic kidney diseasetransforming growth factor-βstandard errors of the meanDimethylsulfoxidecyclooxygenase 2renal fibrosisproximal tubuleSEMPlasminogen activator inhibitor-1areca nutCKDextracellular signal-regulated kinase
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Authors
Sheng-Hsuan Lin, Shean-Jaw Chiou, Wan-Ting Ho, Chao-Tang Chuang, Lea-Yea Chuang, Jinn-Yuh Guh,