| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5858976 | Toxicology | 2015 | 76 Pages |
Abstract
In conclusion, we established and characterized a cell model, which could be used for testing drugs with idiosyncratic mitochondrial toxicity.
Keywords
TMPDMethylmalonyl-CoATMRMDMEMSDSΔΨmFCCPHEPESEGTA4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidBSADMSODulbecco's modified Eagle MediumMTTROSbovine serum albuminethylene glycol tetraacetic acidDimethyl sulfoxideSODsodium dodecyl sulfateMitochondrial toxicityIdiosyncratic hepatotoxicitySuperoxide dismutasetetramethylrhodamine methyl estermethylthiazolyldiphenyl-tetrazolium bromideMitochondrial membrane potentialcobalaminHPLChigh-performance liquid chromatographyCblVitamin B12 deficiencyReactive oxygen species
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![Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: A cell model for idiosyncratic toxicity](/preview/png/5858976.png "First Page Preview: Impaired mitochondrial function in HepG2 cells treated with hydroxy-cobalamin[c-lactam]: A cell model for idiosyncratic toxicity")
Authors
Patrizia Haegler, David Grünig, Benjamin Berger, Stephan Krähenbühl, Jamal Bouitbir,