Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation

Article ID	Journal	Published Year	Pages	File Type
5859103	Toxicology	2015	11 Pages	PDF

Keywords

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide DMEM hepatoma tissue culture Triflupromazine TFP HTC MPT PTZ EC50 CPZ IMP PHT DFT MTT O/W Δψ mitochondrial permeability transition Imipramine Trifluoperazine Thioridazine Structure-activity HTC cells Cytotoxicity Fluphenazine Phenothiazine lactate dehydrogenase LDH Cell death Phenothiazine derivative Density functional theory half maximal effective concentration Mitochondrial transmembrane potential Propidium iodide chlorpromazine

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation

Authors

Priscila A. de Faria, Fernanda Bettanin, Rodrigo L.O.R. Cunha, Edgar J. Paredes-Gamero, Paula Homem-de-Mello, Iseli L. Nantes, Tiago Rodrigues,