Article ID Journal Published Year Pages File Type
5859327 Toxicology 2013 7 Pages PDF
Abstract

•Zeranol administered at 1-100 mg/kg/day demonstrated an increasing trend of fetal resorption and early delivery in mice.•Placental expression of Cdk2 and 4, Cyclin D1 and Bcl-xL were reduced mostly in mice treated with ≥10 mg zeranol/kg/day.•Increased pErk-1 and 2 were also observed in the placentae of zeranol-treated mice.

Mycotoxins are chemicals produced by fungus and many of them are toxic to humans. Zeranol is a mycotoxin used to promote growth in cattle in North America; yet such a practice draws concern about the residual compound in meat in European countries. In the present study, the toxicity of zeranol was tested in a mouse model for reproduction. Pregnant ICR mice were given p.o. daily doses of zeranol at 0, 1, 10, 100 mg/kg for 4 days (from E13.5 to E16.5). Increased rates of fetal resorption at late gestation (E17.5) and preterm birth (

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Life Sciences Environmental Science Health, Toxicology and Mutagenesis
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