| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5859344 | Toxicology | 2013 | 11 Pages |
Abstract
⺠ROS-induced time-dependent gene expression profiles were identified in HepG2 cells. ⺠Different types of ROS-induced temporal pathway changes were found in HepG2 cells. ⺠Early ROS-induced acute stress response changed into compound-specific responses. ⺠We detected an expression profile that could identify chemical-induced ROS in HepG2.
Keywords
RIPAPBSFormamido Pyrimidine Glycosylase8-oxo-dGFPGDMPODEGstBHESRCDFRMAHCADNPHRT-PCR2,4-dinitrophenylhydrazine3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide8-oxo-2′-deoxyguanosineNERHCCMTTReal time PCRROSradioimmunoprecipitation bufferhierarchical clustering analysisOxidative stresstail momentElectron spin resonanceStemHepG2 cellsLiver toxicityantioxidant response elementsPhosphate buffered salineRobust multi-array averageAREtert-butyl hydroperoxideDifferentially expressed genesHepatocellular carcinomaReactive oxygen species
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Authors
L. Deferme, J.J. Briedé, S.M.H. Claessen, D.G.J. Jennen, R. Cavill, J.C.S. Kleinjans,