| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5859433 | Toxicology | 2013 | 10 Pages |
Abstract
In conclusion, ERG observations were very similar to those described in humans. Comparable ERG modifications, histopathology and immunohistochemistry findings were observed in the retina of both rat strains suggesting that melanin pigment is unlikely involved. chloroquine-induced impairment of synaptic vesicle transport, likely related to disruption of neurofilaments was identified and non-previously reported. This new mechanism of toxicity may also be responsible for the burry vision described in humans chronically treated with chloroquine.
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Authors
Stéphane Lezmi, Najla Rokh, Gérard Saint-Macary, Michael Pino, Valérie Sallez, Françoise Thevenard, Nigel Roome, Serge Rosolen,