| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5859598 | Toxicology | 2012 | 9 Pages |
Abstract
⺠Pb2+ significantly inhibited the induction of CYP1A1 through transcriptional and posttranslational mechanisms. ⺠The transcriptional mechanism is evidenced by the decrease in XRE- and increase in ARE-reporter genes. ⺠The posttranslational mechanism is evidenced by the ability of HO-1 chemical inhibitors and HO-1 knockdown to restore of the Pb2+-mediated effect.
Keywords
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Authors
Hesham M. Korashy, Ayman O.S. El-Kadi,