| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5859601 | Toxicology | 2012 | 6 Pages |
Abstract
⺠rNF-kB-Luc mice inhaled a range of doses of endotoxin to upregulate NF-kB. ⺠Mice developed marked inflammation based on neutrophilia and cytokine production. ⺠We evaluated NF-kB signaling in vivo over time by bioluminescence imaging. ⺠Imaging was far less sensitive than measuring neutrophils or cytokines in lung lavage. ⺠This imaging method was useful only at unrealistically-high doses of endotoxin.
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Authors
Suzana HaÄina, Christine L. Wohlford-Lenane, Peter S. Thorne,