Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5859613 | Toxicology | 2012 | 6 Pages |
Abstract
Among non-smokers, higher concentrations of GA-Hb were associated to a higher hazard rate of breast cancer specific mortality (HR (95% CI): 1.63 (1.06-2.51)), the hazard rate among women diagnosed with estrogen receptor positive tumors was (HR (95% CI): 2.23 (1.38-3.61)). For AA-Hb the tendency was similar, but only statistically significant among those with estrogen receptor positive tumors (HR (95% CI): 1.31 (1.02-1.69)). In conclusion, the present study indicates that pre-diagnostic exposure to acrylamide may be related to mortality among breast cancer patients and that this may especially concern the most endocrine related type of breast cancer.
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Authors
Anja Olsen, Jane Christensen, Malene Outzen, Pelle Thonning Olesen, Henrik Frandsen, Kim Overvad, Jytte Halkjær,