| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5859630 | Toxicology | 2012 | 9 Pages |
Abstract
⺠Acetylcholinesterase (AChE) is a target of Mn in the central nervous system. ⺠Mn inhibits AChE, representing a novel mechanistic finding for its mode of action. ⺠AChE inhibition may trigger or contribute to the development of oxidative stress. ⺠Excess Mn can trigger the release of inflammatory mediators. ⺠AChE activity may serve as an early biomarker of Mn neurotoxicity.
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Authors
Dinamene Santos, Dejan Milatovic, Vanda Andrade, M. Camila Batoreu, Michael Aschner, A.P. Marreilha dos Santos,