Galantamine rescues lead-impaired synaptic plasticity in rat dentate gyrus

Article ID	Journal	Published Year	Pages	File Type
5859667	Toxicology	2011	7 Pages	PDF

Abstract

âº Galantamine does not affect lead accumulation in hippocampus. âº Galantamine restores lead-impaired synaptic transmission in dentate gyrus. âº Galantamine reverses lead-impaired short-term synaptic plasticity in dentate gyrus. âº Galantamine recovers lead-impaired LTP/DP in dentate gyrus.

Keywords

NMDA VDCC L-VDCC ACh receptors LFS mGluR PKC HFS NO synthase AP-1 Depotentiation N-methyl-d-aspartate NF-κB AChRs CaMKII AMPA nAChR 5-HT Jnk PPF NOS 5-hydroxytryptamine c-Jun N-terminal kinases Ca2+/calmodulin-dependent protein kinase II EPSP I/O MAPK ACh Acetylcholine 7-Chlorokynurenic acid α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid γ-aminobutyric acid Population spike long-term depression paired-pulse facilitation long-term potentiation LTP Lead dentate gyrus nuclear factor-κB activating protein-1 LTD Rat Nitric oxide input/output excitatory postsynaptic potential Protein kinase mitogen-activated protein kinase Voltage-dependent calcium channel GABA Galantamine Metabotropic glutamate receptor