Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5859991 | Toxicology Letters | 2015 | 11 Pages |
Abstract
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition in vivo differed for VX and VR. In vivo spontaneous reactivation was not observed for VX-inhibited AChE while VR-inhibited AChE was much faster spontaneously reactivated than expected and AChE inhibition by VR was slower than expected. Progredient BChE inhibition was detected after VX application while VR inhibited BChE weakly. Possible explanation may be impact of the agents on hemodynamics and different metabolisms. Thus, due to increase of the V agents' blood concentration after atropine administration (depot release) the present standard therapy should be thoroughly reconsidered.
Keywords
BTChs.c.i.v.PEICAESFiO2CarboxylesterasesATCHBChEbutyrylcholinesteraseDTNBPTESMRMSSARussian VXAChAChEAcetylthiocholine iodideinternal standardAcetylcholineAcetylcholinesteraseEnantiomersIsofluraneEnantiomeric excessToxicokineticstabunOrganophosphorus compoundsDissociation constantIntravenoussubcutaneousSarinSomanCyclosarinIntramuscularPhosphotriesterasesi.m.multiple reaction monitoringCHEkobsCholinesterasePositive electrospray ionization
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Authors
Georg Reiter, Susanne Müller, Ira Hill, Kendal Weatherby, Horst Thiermann, Franz Worek, John Mikler,