Assessment of drug delivery and anticancer potentials of nanoparticles-loaded siRNA targeting STAT3 in lung cancer, in vitro and in vivo

Article ID	Journal	Published Year	Pages	File Type
5860388	Toxicology Letters	2014	13 Pages	PDF

Abstract

- PEI-PLGA is a promising carrier for delivery of siRNA targeting STAT3.
- STAT3 siRNA nanoparticle shows anti-proliferative effects on A549 cells, in vitro.
- STAT3 siRNA nanoparticle regresses tumor growth in Balb/c mice.
- STAT3 siRNA nanoparticle crosses blood brain barrier (BBB).

Keywords

PLGA STAT3 PEI BAP IL-6 DMEM FITC Dulbecco's modified Eagle's medium RNA interference Small interfering RNA RNAi siRNA Sodium arsenite interleukin-6 Benzo[a]pyrene Drug delivery BBB blood brain barrier Lung cancer Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)fluorescein isothiocyanate Mice poly(lactide-co-glycolide)Polyethylenimine

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

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Assessment of drug delivery and anticancer potentials of nanoparticles-loaded siRNA targeting STAT3 in lung cancer, in vitro and in vivo

Authors

Jayeeta Das, Sreemanti Das, Avijit Paul, Asmita Samadder, Soumya Sundar Bhattacharyya, Anisur Rahman Khuda-Bukhsh,