Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5860463 | Toxicology Letters | 2014 | 8 Pages |
Abstract
Abacavir is one of the options for combined anti-HIV therapy. Although individual susceptibilities to adverse effects differ among patients, abacavir is associated with idiosyncratic hypersensitivity drug reactions and an increased risk of cardiac dysfunction. This review highlights the current knowledge on abacavir metabolism and discusses the potential role of bioactivation to an aldehyde metabolite, capable of forming protein adducts, in the onset of abacavir-induced toxic outcomes.
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Authors
Nádia M. Grilo, Catarina Charneira, Sofia A. Pereira, EmÃlia C. Monteiro, M. Matilde Marques, Alexandra M.M. Antunes,