| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860567 | Toxicology Letters | 2013 | 8 Pages |
Abstract
⺠No effective antidote exists against paraquat (PQ) poisonings. ⺠Doxorubicin protects against PQ cytotoxicity inducing P-gp. ⺠Doxorubicin protects against PQ cytotoxicity inhibiting choline uptake system. ⺠Compounds that both promote PQ efflux and limit PQ uptake can be used as antidotes.
Keywords
PBSHPQATP-binding cassette sub-family B member 1NEAAP-gpMDR1EPQhemicholinium-3HC-3ABCB1SPEMDRDMEMDOXFBSBSADulbecco's modified Eagle's mediumMTTP-glycoproteinbovine serum albuminEDTASolid-phase extractionnon-essential amino acidsethylenediamine tetraacetic acidDoxorubicinfetal bovine serumCaco-2 cellsPhosphate buffered saline solutionParaquat
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Authors
Renata Silva, Helena Carmo, Vânia Vilas-Boas, Paula Guedes de Pinho, Ricardo Jorge Dinis-Oliveira, Félix Carvalho, Isabel Silva, Paulo Correia-de-Sá, Maria de Lourdes Bastos, Fernando Remião,