| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860638 | Toxicology Letters | 2013 | 6 Pages |
Abstract
⺠This is the first report on global DNA methylation in brain and liver following chronic heroin or cocaine treatment. ⺠The % 5-MedC content of DNA is higher in mouse brain compared to liver. ⺠Neither heroin nor cocaine affects global DNA methylation in the liver and brain. ⺠Our finding is surprising since cocaine administration induced gross morphological changes in the liver. ⺠Hyper- and hypo-methylation may cancel out in different anatomical regions or genomic sites.
Keywords
DnmtPP1CDNA demethylaseMOPrAP1CDKL5OPRM1PKCɛCpG5-methyl-2′-deoxycytidineHPLC-UVNACPFCDDMLC-MS2′-deoxyadenosine2′-deoxycytidine2′-deoxyguanosinecyclin-dependent kinase-like 5DNA methyltransferaseSp1Thymidineglobal Cytosine-phosphate-GuanineLiquid chromatography-mass spectrometryFosBprefrontal cortexDNA methylationSpecificity protein 1BrainHeroinNucleus accumbensactivator protein 1Protein kinase C epsilonoptical densityLiverCocaineguanosine
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Authors
Domniki Fragou, Panos Zanos, Sofia Kouidou, Samuel Njau, Ian Kitchen, Alexis Bailey, Leda Kovatsi,