| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860644 | Toxicology Letters | 2013 | 9 Pages |
Abstract
⺠Manganese chloride promotes oxidative DNA damage in cultured SH-SY5Y neuronal cells. ⺠The accumulated DNA damage resulted in cell death via an apoptotic pathway. ⺠DNA strand breaks/thymine lesions were measured by comet and mass spec analysis. ⺠The oxidative DNA damage may be associated with Mn-induced reactive oxygen species. ⺠The addition of exogenous antioxidants can reduce the accumulated DNA damage.
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Authors
Adrienne P. Stephenson, Jeffrey A. Schneider, Bryant C. Nelson, Donald H. Atha, Ashok Jain, Karam F.A. Soliman, Michael Aschner, Elizabeth Mazzio, R. Renee Reams,