| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860674 | Toxicology Letters | 2012 | 10 Pages |
Abstract
⺠Pharmacologic ER stress induced by tunicamycin (TM) induces a quick NASH state in vivo. ⺠TM leads to dramatic increase in cleavage of sterol regulatory element-binding protein in the liver. ⺠TM up-regulates lipogenic genes, but down-regulates the genes in lipolysis and FA oxidation. ⺠TM activates NF-κB and expression of genes encoding pro-inflammatory cytokines in the liver.
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Authors
Jin-Sook Lee, Ze Zheng, Roberto Mendez, Seung-Wook Ha, Youming Xie, Kezhong Zhang,