| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860687 | Toxicology Letters | 2012 | 7 Pages |
Abstract
⺠GH secretion and action on liver gene expression are sexually dimorphic. ⺠Bisphenol is an endocrine disruptor which may alter brain sexual differentiation. ⺠Neonatal administration of bisphenol increased pituitary GH and liver IGFI content in adult female rats. ⺠Neonatal bisphenol defeminized liver Cyp2c12, Adh1 and Hnf6 expression. ⺠Early exposure to BPA may compromise liver capacity for metabolic detoxification.
Keywords
CISLOAELRIAGHRHCytokine-inducible SH2-containing proteinIGF-IPRLRGAPDHADHPNDCyPCYP2C11MUPSOCS2Growth-hormone-releasing hormoneHNF6BPACYPsAlcohol dehydrogenaseBisphenolBisphenol ASexual dimorphismradioimmunoassaypostnatal dayCytochrome P450Insulin-like growth factorGrowth hormonearbitrary unitspolymerase chain reactionPCRMajor urinary proteinProlactinLiverglyceraldehyde 3-phosphate dehydrogenaseprolactin receptor
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Authors
Maria Cecilia Ramirez, Nadia Soledad Bourguignon, Maria Marta Bonaventura, Victoria Lux-Lantos, Carlos Libertun, Damasia Becu-Villalobos,