| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860692 | Toxicology Letters | 2012 | 7 Pages |
Abstract
⺠The metabolism of deoxynivalenol-3-glucoside (D3G) in rats was studied. ⺠Urine and feces were analyzed by a validated LC-MS/MS biomarker method. ⺠D3G was readily hydrolyzed to deoxynivalenol (DON) during digestion. ⺠Most D3G was metabolized by the gut microbiota and recovered in feces. ⺠D3G is of considerably lower toxicological relevance than DON, at least in rats.
Keywords
ACNdeoxynivalenol-glucuronideDON-GlcAJECFADOM-1b.w.D3GDeoxynivalenolSSEADMESPELOQSRMMS/MSUrineSolid phase extractionAcetonitrilecollision energyRodentLOD یا Limit of detectionde-epoxy deoxynivalenolDONMass spectrometryTandem mass spectrometryMethanolJoint FAO/WHO Expert Committee on Food Additiveslimit of quantificationlimit of detectionFecesMeOHselected reaction monitoringbody weightdeclustering potentialhigh performance liquid chromatographyHPLC
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Authors
Veronika Nagl, Heidi Schwartz, Rudolf Krska, Wulf-Dieter Moll, Siegfried Knasmüller, Mathias Ritzmann, Gerhard Adam, Franz Berthiller,