Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice

► Fructose induces hepatic lipid accumulation and activates hepatic SREBP-1c. ► Fructose induces hepatic ER stress and decreases hepatic Insig-1 protein. ► PBA reduces fructose-induced hepatic ER stress and Insig1 depletion. ► PBA inhibits hepatic SREBP-1c activation and alleviates hepatic lipid accumulation. ► ER stress is involved in hepatic lipid accumulation in fructose-fed mice.