Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5860699 | Toxicology Letters | 2012 | 12 Pages |
Abstract
⺠Fructose induces hepatic lipid accumulation and activates hepatic SREBP-1c. ⺠Fructose induces hepatic ER stress and decreases hepatic Insig-1 protein. ⺠PBA reduces fructose-induced hepatic ER stress and Insig1 depletion. ⺠PBA inhibits hepatic SREBP-1c activation and alleviates hepatic lipid accumulation. ⺠ER stress is involved in hepatic lipid accumulation in fructose-fed mice.
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Authors
Cheng Zhang, Xi Chen, Ren-Min Zhu, Ying Zhang, Tao Yu, Hua Wang, Hui Zhao, Mei Zhao, Yan-Li Ji, Yuan-Hua Chen, Xiu-Hong Meng, Wei Wei, De-Xiang Xu,