| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860706 | Toxicology Letters | 2012 | 10 Pages |
Abstract
⺠Hepatic gene expression profiles regulated by receptors CAR and PXR were evaluated. ⺠Results of microarray and qPCR analyses showed convergence or divergence of CAR and PXR regulated gene expression profiles. ⺠Basal gene expression is sometimes altered by the knockout of CAR or PXR. ⺠The current results provide further insight into CAR and PXR-dependent gene regulation.
Keywords
Retinoid X receptorhepatocyte nuclear factor-41,4-bis[2-(3,5-dichloropyridyloxy)]benzeneSULTHNF-4αPXRRXRTCPOBOPABCPCNCyPAMPKPPARUGTGSTRT-PCRAMP-activated protein kinaseUDP-glucuronyltransferaseDrug-metabolizing enzymeDrug transporterssulfotransferaseCytochrome P450PhenobarbitalCARreverse transcriptase–polymerase chain reactionATP binding cassetteglutathione S-transferaseconstitutive androstane receptorperoxisome proliferator-activated receptorPregnane X receptorNuclear receptor
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Authors
Hiroki Tojima, Satoru Kakizaki, Yuichi Yamazaki, Daichi Takizawa, Norio Horiguchi, Ken Sato, Masatomo Mori,