Article ID Journal Published Year Pages File Type
5860715 Toxicology Letters 2011 7 Pages PDF
Abstract
► DEHP inhibits cell proliferation, induce Neuro-2a cells apoptosis. ► DEHP activate expression of the PPARγ and Trim17 protein. ► PPARγ agonist (troglitazone) enhanced DEHP-induced Trim17 protein expression and PPARγ antagonist (GW9662) reversed DEHP-induced Trim17 protein expression. ► DEHP activates the Trim17 protein via PPARγ leading to cleavage pro-caspase-3 and apoptosis.
Keywords
Related Topics
Life Sciences Environmental Science Health, Toxicology and Mutagenesis
Preview
Activation of Trim17 by PPARγ is involved in Di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells
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