Dimethyl sulfoxide (DMSO) attenuates the inflammatory response in the in vitro intestinal Caco-2 cell model

Article ID	Journal	Published Year	Pages	File Type
5860719	Toxicology Letters	2011	8 Pages	PDF

Abstract

âº DMSO at low concentrations (0.1-0.5%) modulated the intestinal inflammatory response in vitro. âº DMSO reduced IL-6 and MCP-1 secretions in inflamed Caco-2 cells. âº DMSO decreased prostaglandin-E2 production related to cyclooxygenase-2 activity. âº DMSO inhibited the gene transcription for several proinflammatory proteins.

Keywords

PLA2 nucleotide-binding oligomerization domain containing 2 DMS chemokine (C–C motif) ligand 5 PPAR ILR MCP-1 IFN-γ PGE2 NOD2 iNOS SOD2 VCAM-1 IBD ICAM-1 MIP TLDA IFNGR1 DMSO2 COX LPS TaqMan low density array TNFα NF-κB DMSO MAPK cyclooxygenase phospholipase A2 Intestinal inflammation interleukin Inflammatory bowel disease tumor necrosis factor alpha Dimethyl sulfide Dimethyl sulfoxide DAY Caco-2 cells Intestinal epithelial cells inducible nitric oxide synthase Superoxide dismutase 2 Cytokines nuclear factor κB lactate dehydrogenase LDH lipopolysaccharide RANTES Intercellular adhesion molecule 1 Monocyte chemotactic protein-1 macrophage inflammatory protein vascular cell adhesion protein 1 mitogen-activated protein kinase Prostaglandin E2 IECs Interferon gamma interleukin receptor peroxisome proliferator-activated receptor