| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860722 | Toxicology Letters | 2011 | 11 Pages |
Abstract
⺠1-Nitropyrene increases apoptosis and lipid accumulation in hepatoma cells. ⺠1-NP modifies cholesterol and fatty acids content. ⺠1-NP alters the expression and activities of two enzymes involved in lipid homeostatsis, the steaoyl-CoA desaturase 1 (SCD1) and the AMP-dependent protein kinase (AMPK). ⺠1-NP-induced apoptosis is caspase- and AMPK-dependent, and is associated to a decrease of SCD1 expression.
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Authors
N. Podechard, X. Tekpli, D. Catheline, J.A. Holme, V. Rioux, P. Legrand, M. Rialland, O. Fardel, D. Lagadic-Gossmann, V. Lecureur,