| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860725 | Toxicology Letters | 2011 | 11 Pages |
Abstract
⺠Duloxetine does not cause irreversible TDI of CYP1A2, 2B6, 2D6, 2C19 and 3A4/5. ⺠Thiophene ring of duloxetine does not undergo bioactivation. ⺠Hepatotoxicity is possibly related to epoxidation of duloxetine's naphthyl ring.
Keywords
GSHAPAPQTOFMSDDICYP450HLMSNRIMRMCYP2C19ACNGSH-EECYP1A2ESICYP3A4CYP2B6Reduced l-glutathioneCYP2D6LC/MS/MSm/zcytochrome P450 enzymesAcetaminopheninternal standardAcetonitrilePyroglutamic aciddrug–drug interactionmass-to-chargeMBIsemicarbazideMass spectrometryMechanism-based inactivatorHuman Liver Microsomesmultiple reaction monitoringhigh performance liquid chromatographyliquid chromatography–tandem mass spectrometryHPLCkobsGluelectrospray ionization
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Authors
Chun Yip Chan, Lee Sun New, Han Kiat Ho, Eric Chun Yong Chan,