| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860774 | Toxicology Letters | 2011 | 9 Pages |
Abstract
⺠Crotonaldehyde induces HO-1 expression in human umbilical vein endothelial cells (HUVECs). ⺠Crotonaldehyde-induced HO-1 expression via the PKC-δ-p38-Nrf2-ARE pathway. ⺠Suppression of HO-1 expression by transfection with Nrf2 siRNA or treatment with HO-1 specific inhibitor ZnPP increased apoptosis of crotonaldehyde-stimulated HUVECs. ⺠HO-1 serves as a mechanism for protection of cells from oxidative stress in crotonaldehyde-stimulated endothelial cells.
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Authors
Seung Eun Lee, Seong Il Jeong, Gun-Dong Kim, Hana Yang, Cheung-Seog Park, Young-Ho Jin, Yong Seek Park,