| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860797 | Toxicology Letters | 2011 | 9 Pages |
Abstract
⺠Liver IGF-1 deficiency attenuates or abolishes the sex difference in cardiac contractile function and intracellular Ca2+ handling. ⺠Sex difference in cardiac function is associated with sex difference in intracellular Ca2+ regulatory proteins SERCA2a, Na+-Ca2+ exchanger and phospholamban, which may be alleviated by liver IGF-1 deficiency. ⺠IGF-1 may interact with sex hormones to regulate cardiac contractile function and intracellular Ca2+ handling.
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Authors
Asli F. Ceylan-Isik, Qun Li, Jun Ren,