| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860798 | Toxicology Letters | 2011 | 5 Pages |
Abstract
⺠N-Nitrosodiethylamine (NDEA)-induced genotoxicity and cytotoxicity in the presence of phenobarbital (PB). ⺠PB prior to NDEA treatment decreases the number of micronucleated cells. ⺠NDEA induces an increased in the number of chromosomal aberrations after pre-treatment with PB. ⺠NDEA-treatment induced synergistic effect in the expression of the CYP2B1 and CYP2B2 mRNA. ⺠Alterations of CYP expression by PB increased the cytotoxicity and genotoxicity of NDEA leading to the final genotoxic metabolite.
Related Topics
Life Sciences
Environmental Science
Health, Toxicology and Mutagenesis
Authors
Claudia A.F. Aiub, Gabriele Gadermaier, Izaura Oliveira, Israel Felzenszwalb, Fátima Ferreira, Luis Felipe Ribeiro Pinto, Peter Eckl,