Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO2-PCBs

Article ID	Journal	Published Year	Pages	File Type
5860802	Toxicology Letters	2011	8 Pages	PDF

Abstract

âº We investigated the effects of NDL-PCBs and their metabolites on aromatase activity and glucocorticoid receptor. âº Most NDL-PCBs and MeSO2-PCBs had no effect or were mild aromatase activity inhibitors and (anti-) glucocorticoids. âº The tested OH-PCBs were stronger aromatase activity inhibitors and (anti-) glucocorticoid than the tested NDL-PCBs or MeSO2-PCBs.

Keywords

non-dioxin-like PCBs human risk assessment Aromatase activity glucocorticoid receptor

Related Topics

Life Sciences Environmental Science Health, Toxicology and Mutagenesis

Preview

Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO2-PCBs

Authors

Elsa C. Antunes-Fernandes, Toine F.H. Bovee, Frieda E.J. Daamen, Richard J. Helsdingen, Martin van den Berg, Majorie B.M. van Duursen,