| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860823 | Toxicology Letters | 2011 | 10 Pages |
Abstract
⺠iNOS inhibition promotes insulin resistance, anomalies in cardiac contractile function and intracellular Ca2+ handling. ⺠Akt2 knockout attenuates iNOS inhibition-induced cardiac contractile and intracellular Ca2+ derangement. ⺠Akt2 knockout promotes intracellular Ca2+ regulatory proteins SERCA2a and phospholamban phosphorylation. ⺠Neither iNOS inhibition nor Akt2 knockout significantly affects post-insulin receptor and stress signaling.
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Authors
Nathan D. Roe, Jun Ren,