Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5860829 | Toxicology Letters | 2011 | 8 Pages |
Abstract
⺠Microcystin-LR causes reorganization of cytoskeleton and inhibition of PP2A simultaneously in a human liver cell line. ⺠MC-LR markedly increased the level of HSP27 phosphorylation with the enhanced distribution of phosphorylated HSP27 to the cytoskeleton. ⺠The increased HSP27 phosphorylation is regulated through p38MAPK and JNK, possibly as a consequence of PP2A inhibition.
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Authors
Yu Sun, Guan-min Meng, Zong-lou Guo, Li-hong Xu,