| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5860832 | Toxicology Letters | 2011 | 5 Pages |
Abstract
⺠1,2:3,4-Diepoxybutane (DEB) is the most genotoxic metabolite of 1,3-butadiene (BD). ⺠DEB blood levels were determined in rodents at BD concentrations down to 1 ppm. ⺠DEB blood levels in mice increased from 5 nM at 1 ppm BD to 1860 nM at 1250 ppm. ⺠DEB levels in rats were 1 nM at 1 ppm BD and reached a plateau of 100 nM at 200 ppm. ⺠The data explain why the tumorigenic potency of BD is low in rats compared to mice.
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Authors
György András Csanády, Robert Steinhoff, Martin Bernhard Riester, Brigitte Semder, Christian Pütz, Qiang Li, Nadine Richter, Winfried Kessler, Dominik Klein, Johannes Georg Filser,